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Colorado Department of Agriculture Certified Premium Nutrient-Rich Hemp CBD Oil that is CO2 extracted without organic solvents to yield a pure hemp extract that preserves the native cannabinoid profile of the plant. Our CBD Oil is carefully blended with 100% pure coconut oil so your body can absorb the CBD more easily and effectively.
Place drops under the tongue and keep for a minimum of 60 seconds before swallowing. Store in a cool, dry place, away from direct sunlight. Keep away from children.
1. Reduced Risk of Diabetes and Obesity.
2. Better Cholesterol Profiles and Lowered Risk of Cardiovascular Disease.
3. Reduced Risk of Cancer.
4. Helps Maintain Brain Health and Create Resilience to Trauma and Degeneration.
5. Protects against Bone Disease and Broken Bones.
6. Protects and Heals the Skin.
7. Helps with Anxiety and Stress.
1. Is CBD oil legal?
Yes. Usage of CBD Oil is absolutely legal.Most CBD oil is produced from industrial hemp, the same plant used to make hemp textiles and hemp seeds.
2. How do I take CBD Oil and at what dosage?
Before adding CBD oil to your regimen, as with any supplement, be sure to check with your doctor to make sure that it's a good choice for you.
3. Are there side effects from taking CBD oil?
CBD oil is generally considered to be safe for most people.
4. How much do CBD oil products cost?
CBD oil generally costs between $40 and $100.
CBD oils like many other CBD products act in a similar way when introduced to the body. When a hemp product made with CBD is ingested, absorbed, or administered through different means you might wonder how these products interact with you body, as well as how different methods of application work. CBD is a cannabinoid and cannabinoids interact with the body’s endocannabinoid system as well as other targets. The endocannabinoid system is a network of cell receptors, various molecules, and enzymes found in the brain and nervous system which function together to perform specific functions. These functions include a variety of psychological processes including appetite, pain recognition, anxiety, mood, memory, and many more.
Our bodies naturally produce molecules which interact with our endocannabinoid system and CBD is one of multiple phytocannabinoids which are able to interact with our endocannabinoid system. A phytocannabinoid is a cannabinoid whose origin is from a plant. Although CBD is a phytocannabinoid it is still able to interact with the human endocannabinoid system because CBD still fits the cell receptors in the endocannabinoid system. Cell receptors come in various forms such as local or distant receptors. Local receptors function through nerve synapse transmissions in the nervous system, and distant receptors rely on hormones and other binding factors to send signals throughout the body to various receptors. Cell receptors will only allow certain molecules to bind to them. Each receptor site has a specific shape which will only allow certain molecules to bind to and activate them. This also means cells have multiple different types of cell receptors on their surface and each of these receptors respond specifically to their specific stimuli. So, any part of the body which is connected to the endocannabinoid system will have receptors specific to molecules, such as CBD, which binds with it.
Two of the endocannabinoid receptors that are the most prominent are the CB1 and CB2 receptors. The CB1 receptors are mainly found in the brain, nervous system, as well as certain tissues and organs. The CB2 receptors are mostly found in the lymphatic system, specifically white blood cells. Studies have also discovered some CB2 receptors in the brain however, CBD often does not bind with the CB2 receptors in the brain. The brain houses the largest amount of CB1 receptors which are mainly found in the hippocampus, cerebral cortex, cerebellum, and the basal ganglia. The main functions of these section of the brain include motor functions, behavior, cognition, short-term memory, attention, language, balance, as well as many other functions. This means that these functions are most affected by cannabis intake. THC which is the psychoactive component in marijuana-binds directly to the CB1 receptor however, CBD does not. CBD acts as an inhibitor preventing THC and other molecules from binding to the CB1 receptor by changing the receptor site’s shape. By changing the shape of the receptor site the CBD changes the types of molecules which can bind to the CB1 receptor and helps prevent the binding of THC so the psychoactive effects of it will not occur when taking high-CBD, low-THC products.
The CB2 receptor is mainly located in white blood cells which are part of the immune system. Studies have shown that CBD affects the CB2 receptor however, the direct effects are still unclear. It is believed that CBD indirectly communicates with CB2 to interact with white blood cells. Besides the CB1 and CB2 receptors there are also a few lesser known receptors which interact with CBD. The 5-HTIA receptor is found in most of the same parts of the brain as the CB1 receptor. The 5-HTIA receptor affects mood, appetite, sleep, and pain perception. It is part of the family of receptors referred to as the serotonin receptors. These receptors are named as such because of their ability to interact with the neurotransmitter serotonin.
Another receptor which CBD interacts with is the TRPV-1 receptor. This receptor is part of the peripheral nervous system. The peripheral nervous system is the part of the nervous system which connects the central nervous system to the rest of the body. The main functions of the TRPV-1 receptor are pain recognition, inflammation, and body temperature regulation. It is believed that when CBD binds to the TRPV-1 receptor it weakens its affinity to stimuli. This means that stimuli which would normally cause it to send pain signals to the brain are unable to bind to the TRPV-1 receptor leading to pain relief. If this is truly the case then CBD would be effective in treating conditions where TRPV-1 sensitivity is hightened such as rheumatoid arthritis.
GPR55 is another receptor which CBD interacts with. The cerebellum and osteoblasts, the cells which form the matrix for bones, are the main sources for this receptor. A lot is still unknown about this receptor but it is known that it assists in the maintenance of blood pressure and bone density. When this receptor is disrupted it can overreact leading to conditions such as osteoporosis, cancer, and obesity. Ruth Ross, a scientist at the university of Aberdeen has stated that CBD is an antagonist of the GPR55 receptor meaning CBD can stop GPR55 from over signaling.
The last major cell receptor CBD interacts with is the GABA-A receptor. The GABA-A receptor is located in the central nervous system and is one of two forms of the receptor, the other being the GABA-B receptor. The GABA-A receptor complex normally binds with the neurotransmitter GABA. GABA is widely distributed and utilized throughout the central nervous system and has a calming effect on the body. When CBD binds to the GABA-A receptor it changes the shape of the receptor which affects its ability to bind with GABA and strengthens the calming effects GABA has on the body.
Studies to discover the way CBD and GABA-A interact are underway and making progress towards finding the exact mechanism. A study from 2017 tested the effect of CBD on GABA receptors to see if they could explain CBD’s anti-epileptic, anti-anxiety, and pain relieving features. It was concluded from the study that more a mode of action of CBD on specifically configured GABA-A receptors was found that may be relevant to the anticonvulsant and anti-anxiety effects of CBD.
CBD has been the subject of countless studies and although much is yet to be discovered about CBD a lot is known as well. A 2011 review of over 130 different studies and papers on CBD concluded that CBD is non-toxic in non-transformed cells and does not induce changes on food intake, does not induce catalepsy, does not affect heart rate, blood pressure, body temperature, gastrointestinal transit, and does not alter psychomotor or psychological functions. The studies examined by this review were a mix of in vivo tests conducted on living creatures as well as in vitro tests performed on cells in a closed environment. From tests involving human subjects it was found that patients with psychiatric disorders, including schizophrenia and bipolar disorder, displays positive results after using CBD daily for three to four weeks. Their psychotic symptoms were reduced and they experienced fewer side effects than they had experience on their prescription drugs.
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